The principal inclusion criteria are:

1. Pregnant woman with fetal age estimated from last menstrual period and confirmed where possible by early ultrasound scanning at 20-42 weeks gestational age.
2. Live infants between 23 and 44 weeks gestational age, estimated from the mothers last menstrual period and confirmed where possible by early ultrasound scanning.

The project aims to observe the wide range of normal human development, but also to capture potential abnormalities in brain growth, and therefore fetal and neonatal subjects with high risk of neurodevelopmental disorder, including those in families with high genetic risk of abnormality and those with possible environmental reasons for abnormality, including fetal growth restriction and preterm delivery will be recruited.

The principal exclusion criteria are:

1. Mothers or infants with contraindication to MR imaging, including implanted metallic devices such as orthopedic devices or non-compatible clips to close patent ductus areteriosus.
2. Preterm infants who are too unwell to tolerate the scanning period, despite full intensive neonatal care. This decision would be made by the attending paediatric doctor performing the scan, in conjunction with the medical team caring for the patient.
3. Language difficulties preventing proper communication about the trial and the consent process.